Prescription of non-steroidal anti-inflammatory and antirheumatic drugs in outpatient hypertensive patients




Nallely Aguiñaga-Martínez, Unidad de Medicina Familiar 24, Instituto Mexicano del Seguro Social, Ciudad Mante, Tamaulipas, México
Juan de Dios Zavala-Rubio, Unidad de Medicina Familiar 24, Instituto Mexicano del Seguro Social, Ciudad Mante, Tamaulipas, México
Melissa Ramírez-Ruíz, Unidad de Medicina Familiar 24, Instituto Mexicano del Seguro Social, Ciudad Mante, Tamaulipas, México
Alberto J. Hernández-Garza, Unidad de Medicina Familiar 24, Instituto Mexicano del Seguro Social, Ciudad Mante, Tamaulipas, México
Martín Segura-Chico, Órgano de Operación Administrativa Desconcentrada, Instituto Mexicano del Seguro Social, Tamaulipas, México
Miriam J. De la Mata-Márquez, Hospital General de Zona 3, Instituto Mexicano del Seguro Social, Ciudad Mante, Tamaulipas, México
Dolores Mino-León, Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México


Background: It has been documented that NSAIDs (nonsteroidal anti-inflammatory and antirheumatic drugs) reduce the effectiveness of some antihypertensive drugs. Objective: Analyze the prescription of NSAID and the variables associated in outpatients with hypertension and explore some characteristics of the physicians. Material and methods: Cross-sectional study, included patients with hypertension from the Family Medicine Unit No. 24 in Mante, Tamaulipas. From the patients, sociodemographic data, clinical history and pharmacological treatments were obtained. From the physicians, sociodemographic and academic information were collected. Results: Mean age of the patients was 63 ± 11 years and 31.7% were prescribed NSAIDs. When compare exposed versus non-exposed to NSAIDs, the first had more obesity, higher blood pressure, uncontrolled hypertension, multimorbidity and polypharmacy. The variables associated to the prescription of NSAIDs were: uncontrolled hypertension, multimorbidity and polypharmacy. The 56.7% of the physicians were women, 83.3% with experience >10 years and 33.3% with current certification by the Council in Family Medicine. Conclusions: The inappropriate prescription of NSAIDs revealed the need to implement actions to mitigate the potential risk for the hypertension patients to present a complication.



Keywords: Non-steroidal anti-inflammatory drugs. Antihypertensive agents. Hypertension. Inappropriate prescribing.




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