Nancy Podoswa-Ozerkovsky, Servicio de Dermatología, Instituto Mexicano del Seguro Social (IMSS), Hospital General Regional 1, Ciudad de México, México
Luis G. Vega-Gonzalez, Servicio de Dermatología, Unidos Contra la Psoriasis, Morelia, Michoacán, México
Mario Amaya-Guerra, Servicio de Dermatología, Hospital San Lucas, Monterrey, Nuevo León, México
Fermín R. Garza-González, Servicio de Dermatología, Clínica Hospital, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Constitución, Monterrey, Nuevo León, México
Minerva Gómez-Flores, Servicio de Dermatología, Universidad Autónoma de Nuevo León (UANL), Monterrey, Nuevo León, México
José D. Martínez-Villarreal, Departamento de Medicina Interna, Hospital Universitario José Eleuterio González, UANL, Monterrey, Nuevo León, México
Columba J. Navarro-Romero, Servicio de Dermatología, Hospital General Regional 180, IMSS, Guadalajara, Jalisco, México
Delfina G. Villanueva-Quintero, Servicio de Dermatología, Investigación, Grupo Clínico CATEI, Centro de Atención en Enfermedades Inflamatorias, Guadalajara, Jalisco, México
Generalized pustular psoriasis is a rare, clinically heterogeneous autoinflammatory disease associated with significant morbidity and mortality. There are still many questions and unmet needs regarding basic concepts of the disease, although advances in the knowledge of its pathophysiological and genetic bases are leading to a change in it's concept, classification and treatment. Likewise, these advances have allowed the development of effective treatments with good therapeutic responses. After an exhaustive review of the literature, and based on the clinical experience of the authors, the Mexican Group for the Study of Psoriasis and Immune-Mediated Diseases (PSOMEX) provides in this article current information on the classification, diagnosis, clinical approach and treatment of generalized pustular psoriasis, as well as some recommendations for its management.
Keywords: Generalized pustular psoriasis. PSOMEX. Mexico.