Barbara Peña-Espinoza, Laboratorio de Genómica de la Diabetes, Facultad de Química, Unidad Académica de Ciencia y Tecnología, Universidad Autónoma de México, Mérida, Yucatán
Guadalupe Ortiz, Servicio de Hematología, Hospital General "Dr. Gaudencio González Garza", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México
Carlos Juárez-López, Indesalud, Secretaría de Salud del Estado de Campeche, Campeche. Ciudad de México. México
Ángeles Granados-Silvestre, Laboratorio de Diabetes, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México. México
Marta Menjivar, Laboratorio de Genómica de la Diabetes, Facultad de Química, Unidad Académica de Ciencia y Tecnología, Universidad Autónoma de México, Mérida, Yucatán; Laboratorio de Diabetes, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México. México
Background: Both environmental and genetic factors determine metabolic syndrome (MetS) and eventually result in metabolic diseases. MetS is a national health problem in adults and children, with a higher incidence in Indigenous than mestizo individuals. Objective: Evaluate the association of PPARG/rs1801282, KCNJ11/rs5219, HHEX/rs1111875, HNF4A/rs1800961, ACE-I/D, FTO/rs9939609 and ABCA1/rs9282541 variants with MetS or its components in the Maya children from Yucatan. Material and methods: A total of 508 Maya children of 9 to 13 years were recruited. We analyze the association of genetic variants with MetS in non-obese Maya children by univariate and multivariate models adjusted by sex, age, and BMI. Results: Interestingly, the frequency of MetS in non-obese Maya children from rural and urban areas was 35 % and 39 %, respectively. The genotype-phenotype analysis in rural Maya children revealed that rs9282541-ABCA1 was associated with high glucose (p = 0.011); rs9939609-FTO, with high blood pressure (p = 0.048) and rs1800961-HNF4A, with high insulin and HOMA-IR (p = 0.038, p= 0.043). In urban children, I/D-ECA was associated with high blood pressure (p = 0.022); rs1111875- HHEX, with high triglycerides (p = 0.050) and rs1800961-HNF4A, with low HDL-c (p = 0.048). Conclusions: These findings provide strong evidence of the role of the studied variants in conferring genetic susceptibility to develop MetS in non-obese Maya children from Mexico.
Keywords: Genes. Maya children. Insulin resistance.