Augusto Aguilar-Salazar, Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica; Facultad de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México; Ciudad de México, México
Génesis K. González-Quijano, Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica; Consejo Nacional de Humanidades, Ciencias y Tecnologías; Ciudad de México, México
M. Elizabeth Tejero, Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica, Ciudad de México, México
Guadalupe León-Reyes, Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica, Ciudad de México, México
Obesity is characterized by excess body fat, metabolic dysfunction, and an increased risk of developing other chronic diseases. This review aims to describe the main molecular mechanisms involved in metabolic diseases associated with obesity and to highlight the most recent studies on Nutritional Genomics in the Mexican population. The findings show that in Mexico, multiple observational and experimental investigations have been carried out on the gene-nutrient interaction, and its effect on human health. Changes in the eating pattern towards obesogenic diets and the presence of certain genetic variants can predispose to developing obesity and other disorders. These genetic variants could have a differential impact on each ethnicity;
Keywords: Dyslipidemias. Metabolic diseases. Nutritional genomics. Obesity. Mexican population