Christopher A. Gutiérrez-García, Centro Universitario de Tonalá, Universidad de Guadalajara. Jalisco, México
Martín R. Gutiérrez-Jiménez, Centro Universitario de Tonalá, Universidad de Guadalajara. Jalisco, México
Roberto de J. Sandoval-Muñiz, Región Sanitaria XI Tonalá Capacitación, Secretaría de Salud Jalisco. Jalisco, México
Raúl C. Baptista-Rosas, Centro Universitario de Tonalá, Universidad de Guadalajara; Hospital General de Occidente. Guadalajara, Jalisco, México
Background: Diabetes, which is caused by environmental and genetic factors, has a high global prevalence (10.5%). Some single nucleotide variants (SNVs) modify the activity of glucose transporters such as GLUT2, which plays a significant role in insulin secretion and glucose metabolism. Objective: To analyze the SNVs associated with type 2 diabetes (T2D) in the Mexican population. Material and methods: Reference databases for SNVs registered for SLC2A2 gen associated with T2D in the Mexican population. Results. 83 SNVs were analyzed, identifying 3 relevant variants in Mexican population associated with T2D: rs5404, rs5406 and rs5398, a pathogenic variant with RM >1.0 and p value < 0.05. Conclusions: Detailed genetic analysis and mapping coupled with functional studies are needed to identify the mechanism by which GLUT2 variants influence diabetes development.
Keywords: Type 2 Diabetes mellitus. Mexican people. Single nucleotide polymorphisms. Glucose transporter type 2. Single nucleotide variants.